Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4A
C. Goebl, V. Morris, L. van Dam, M. Visscher, P. Polderman, C. Hartlmueller, H. de Ruiter, M. Hora, L. Liesinger, R. Birner-Gruenberger, H. Vos, B. Reif, T. Madl, T. Dansen
This study shows that cysteine oxidation in p16INK4A leads to amyloid fibril formation, which inactivates its tumor suppressor function.
bioRxiv · Jan 2, 2019Biochemistry