Miltefosine enhances infectivity of miltefosine-resistant Leishmania infantum by attenuating innate immune recognition
D. Bulte, L. Van Bockstal, L. W. Dirkx, M. Van den Kerkhof, C. De Trez, J.-P. Timmermans, S. Hendrickx, L. Maes, G. Caljon
This study shows that miltefosine-resistant Leishmania infantum parasites have reduced in vivo fitness but gain infectivity when exposed to miltefosine, due to suppressed innate immune activation.
bioRxiv · Feb 22, 2021Microbiology