A bacterial inflammation sensor regulates c-di-GMP signaling, adhesion, and biofilm formation.
A. Perkins, D. A. Tudorica, R. D. Teixeira, T. Schirmer, L. Zumwalt, O. M. Ogba, C. K. Cassidy, P. J. Stansfeld, K. Guillemin
This paper identifies a bacterial sensor that detects HOCl, a host-derived oxidant, and links its activation to biofilm formation through a redox-sensitive zinc-cysteine switch.
bioRxiv · Oct 11, 2020Microbiology