C. K. Cassidy

The Structure of ApoB100 from Human Low-density Lipoprotein

This study determines the structure of apoB100 from human LDL using cryo-EM, AlphaFold2, and molecular dynamics, revealing its structural organization and functional domains.

Structure of the Native Chemotaxis Core Signalling Unit from E-gene lysed E. coli cells

The paper presents the structure of the chemotaxis core signaling unit from E. coli cells using cryo-electron tomography and predicts atomic structures using AlphaFold2.

High resolution reconstruction of a Jumbo bacteriophage infecting capsulated bacteria using hyperbranched tail fibers

This study determines the high-resolution structure of a jumbo bacteriophage infecting Klebsiella pneumoniae, revealing its complex tail fibers that enable infection of multiple capsular polysaccharide types.

Structural basis for antagonism of the ubiquitin ligase BIRC6 by SMAC

This study reveals how SMAC antagonizes BIRC6 by binding multiple sites on BIRC6, displacing caspases and inhibiting its ubiquitin ligase activity.

LipIDens: Simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins.

LipIDens uses MD simulations to interpret lipid-like densities in cryo-EM maps of membrane proteins, revealing protein-lipid interactions.

Alternative architecture of the E. coli chemosensory array

The paper presents cryo-electron tomography images of E. coli chemosensory arrays showing a p2-symmetric architecture, differing from the previously described p6-symmetric structure, and proposes molecular models for both.

A bacterial inflammation sensor regulates c-di-GMP signaling, adhesion, and biofilm formation.

This paper identifies a bacterial sensor that detects HOCl, a host-derived oxidant, and links its activation to biofilm formation through a redox-sensitive zinc-cysteine switch.

The unconventional cytoplasmic sensing mechanism for ethanol chemotaxis in Bacillus subtilis

This paper identifies an unconventional ethanol sensing mechanism in Bacillus subtilis where ethanol binds the cytoplasmic signaling domain of McpB and the myoglobin-like sensing domain of HemAT.

Complete structure of the core signalling unit of the E. coli chemosensory array in an optimised minicell strain

The paper presents a 3D map of the E. coli chemosensory core signalling unit using cryo-ET and subtomogram averaging, combined with molecular dynamics simulations to create an atomistic model.