ATP and Substrate Binding Regulates Conformational Changes of Human Peroxisomal ABC Transporter ALDP
c. xiong, L.-N. Jia, M.-H. Shen, W.-X. Xiong, L.-L. Xiong, T.-H. Wang, D. Zhou, Z. Liu, L. Tang
The paper presents Cryo-EM structures of ABCD1 in different conformational states, revealing how ATP and substrate binding regulate its transport mechanism and disease-related mutations.
bioRxiv · Oct 14, 2021 · PreprintBiochemistry