Loss of PRMT5 promotes PDGFRα degradation during oligodendrocyte differentiation and myelination
Sara Calabretta, Gillian Vogel, Zhenbao Yu, Karine Choquet, Lama Darbelli, Thomas B. Nicholson, Claudia L. Kleinman, Stéphane Richard
The paper shows that reduced PRMT5 activity during oligodendrocyte differentiation leads to PDGFRα degradation, promoting myelination by altering Cbl binding.
Developmental Cell · Jul 26, 2018Peer-reviewedMolecular Biology