Stéphane Richard

This study identifies PRMT7 as a negative regulator of CD8+ T cell immunity and demonstrates a PROTAC degrader (MS54) that enhances anti-tumor responses by activating the NF-κB pathway.

This study shows that 3D spheroid culture of NSCLC cells undergoes time-dependent chromatin and transcriptomic changes that improve drug response prediction and correlation with tumors.

This study shows that inhibiting type I PRMTs with MS023 enhances muscle stem cell proliferation and regenerative potential while maintaining stemness.

This study identifies POGZ as a regulator of HP1-dependent DNA repair, showing its role in homology-directed repair and its clinical relevance to White Sutton syndrome.

This study shows that arginine methylation of SARS-CoV-2 N protein by PRMT1 is essential for RNA binding and suppression of stress granules, and inhibiting this methylation reduces viral replication.

The paper identifies DDX5 as an RNA helicase involved in R-loop resolution, showing that PRMT5-mediated arginine methylation of DDX5's RGG/RG motif regulates its interaction with XRN2 and R-loop degradation.

The paper shows that reduced PRMT5 activity during oligodendrocyte differentiation leads to PDGFRα degradation, promoting myelination by altering Cbl binding.