A DNA-barcoded Luria-Delbrück assay resolves mechanisms of adaptation
Kabir B. Husain, Lanijah Flagg, David Pincus, Arvind Murugan
This paper introduces HiDenSeq, a DNA-barcoded Luria-Delbrück assay that uses deep sequencing to analyze adaptation mechanisms by resolving the Luria-Delbrück distribution over four orders of magnitude.
bioRxiv · Oct 16, 2026 · PreprintEvolutionary Biology