Kabir B. Husain

A DNA-barcoded Luria-Delbrück assay resolves mechanisms of adaptation

This paper introduces HiDenSeq, a DNA-barcoded Luria-Delbrück assay that uses deep sequencing to analyze adaptation mechanisms by resolving the Luria-Delbrück distribution over four orders of magnitude.

Direct and indirect selection in a proofreading polymerase

This study examines the evolution of mutation rates in proofreading polymerases by controlling direct and indirect selection, revealing dynamic evolutionary features and trade-offs between mutation rates and short-term fitness.

Input dose differentiation by NF-κB

The paper shows NF-κB differentiates cytokine input doses by using negative feedback loops to track changes in concentration rather than absolute levels.