Synergistic role of riboflavin-auxotrophic Enterococcus for MR1 expression and intra-tumoral mucosal associated invariant T (MAIT) cell activation
Pakhi Birla, Lansaol Yang, W. Shan, Sukara Minamisawa, Omkar Dhaygude, Haritha Padannapurath Manoj, Ying Zheng, Hongni Fan, Hadley E. Beauregard, Kellie Nicole Smith, Fyza Y. Shaikh, Cynthia L. Sears, Drew M. Pardoll, Franck Housseau
The paper identifies riboflavin-auxotrophic Enterococcus spp. that synergize with metabolites to boost MR1 expression and activate MAIT cells in the tumor microenvironment.
bioRxiv · Nov 25, 2025 · PreprintImmunology