Cynthia L. Sears

The paper creates a spatial atlas of early-stage colorectal cancer tumors to identify bacterial niches and their impact on tumor transcriptomes, highlighting C. difficile's significant influence despite low abundance.

This study shows how ETBF reprograms host metabolism to create an oxidative niche that supports its growth in the inflamed gut.

The paper identifies riboflavin-auxotrophic Enterococcus spp. that synergize with metabolites to boost MR1 expression and activate MAIT cells in the tumor microenvironment.

This study shows antibiotic-induced microbiota depletion in mice impairs the pro-regenerative immune response to a biological scaffold, reducing myocyte regeneration and increasing fibrosis.

Multi-probe imaging and 16S rRNA profiling of Malaysian colorectal cancers show that Fusobacterium nucleatum, dominated by subspecies animalis clade 2, is enriched specifically within mucus-invasive tumor biofilms.

This study shows that gut microbiota dysbiosis from enteric infection increases immune cell recruitment to a distant biomaterial implant, affecting the foreign body response.

The paper shows that genotoxic bacteria in the gut accelerate colon cancer in mice, regardless of donor health status.

This study maps tumor evolution and microenvironment dynamics in colorectal cancer using spatial multi-omic data, identifying key genes associated with immune exclusion and prognosis.

This study shows that intestinal bacteria maintain adult enteric neurons via TLR2-induced neurogenesis in mice, with implications for treating colonic motility disorders.

This paper examines how Bacteroides fragilis toxin affects chromatin accessibility and gene expression in colon epithelial cells, linking these changes to colorectal cancer development.