The nephronophthisis protein GLIS2/NPHP7 is required for the DNA damage response in kidney tubular epithelial cells
Lena K. Ebert, Lukas Schloesser, Laura E. Frech, Manaswita Jain, Claudia Dafinger, Max C. Liebau, Thomas R. Benzing, Bernhard Schermer, Gisela G.G. Slaats
This paper shows that GLIS2 is essential for the DNA damage response in kidney cells, leading to DNA damage and cystic kidney disease in a mouse model.
American Journal of Physiology-Renal Physiology · Jul 25, 2025Peer-reviewedCell Biology