Bernhard Schermer

This study identifies INPP5E interactors involved in growth factor signaling, revealing its role in regulating ciliary pathways in fibroblasts.

This paper shows that GLIS2 is essential for the DNA damage response in kidney cells, leading to DNA damage and cystic kidney disease in a mouse model.

The paper introduces a red fluorescent Lifeact marker to study actin morphology in podocytes using intravital imaging and super-resolution microscopy.

The paper develops single-cell damage scores to quantify cellular deterioration in degenerative diseases and applies them to murine and human datasets to identify molecular trajectories of damage.

This paper shows that proximal tubules are sensitive to metabolic acidosis, leading to trafficking defects and lysosomal damage, and that bicarbonate therapy can prevent these issues.

This study shows that loss of Bbs8 in mice causes cystic kidney disease by reducing ciliary alpha-tubulin acetylation through increased HDAC2 activity.

This paper identifies a VHL-1/HIF-1/SQRD-1/COL-88 axis linking extracellular matrix formation with longevity in C. elegans, showing that loss of VHL-1 increases lifespan and alters collagen expression.

This study identifies aging-associated increases in transcriptional elongation speed across multiple species and shows that reducing this speed extends lifespan.

This paper introduces a fast and simple optical clearing and swelling protocol for 3D visualization of kidney ultrastructure using conventional confocal microscopy.

The paper identifies mTOR-activating mutations in RRAGD causing kidney tubulopathy and cardiomyopathy (KICA) syndrome through genetic and functional analyses of patient cohorts.

This study identifies PCK2 as a biomarker for renal function 12 months after living donor kidney transplantation using proteomic analysis of urinary extracellular vesicles.

The paper presents a comprehensive analysis of AATF's RNA interactions, revealing its role in ribosome biogenesis through binding to pre-rRNA and mRNAs of ribosome factors.

This paper introduces an optimized electroporation method for CRISPR/Cas9 genome editing in murine zygotes, achieving 100% successful genome editing with reduced embryo damage.

The paper develops a method to analyze individual nephron proteomes in kidney disease, identifying lysosomal protein overexpression as a key mechanism in proteinuric diseases.