Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids
David Taborsky, Fabiola Valdivia-Francia, Neguin Ranjbar, Laura Llop-Grau, Clara Duré, Umesh Ghoshdastider, Peter F. Renz, Ramona Weber, Merve Yiğit, Aleksei Mironov, Katie Hyams, Stefano Vianello, Mihaela Zavolan, Matthias P. Lütolf, Ataman Sendoel
This study identifies mRNA deadenylation as a key mechanism regulating body plan formation in mouse gastruloids by affecting mesoderm and endoderm differentiation.
bioRxiv · Jul 22, 2025 · PreprintDevelopmental Biology