The modulatory role of early-life experiences and sex on cognitive resilience in APP/PS1 mice over time
Maria Carrigan, Jeniffer Sanguino‐Gómez, Melis Bayer-Var, Olga Minko, Alise Bobkova, Eva Ruzicka, Laura Lopez-Fedjajeva, Niek S. Renckens, Laurent Givalois, Paul John Lucassen, Rik Ossenkoppele, Harm J. Krugers
This study examines how early-life handling and sex influence cognitive resilience and pathology in APP/PS1 mice over time, finding improved memory and reduced pathology in handled mice and better cognition in females despite greater pathology.
bioRxiv · Oct 5, 2026 · PreprintAnimal Behavior & Cognition