Paul John Lucassen

This study examines how early-life handling and sex influence cognitive resilience and pathology in APP/PS1 mice over time, finding improved memory and reduced pathology in handled mice and better cognition in females despite greater pathology.

The paper identifies unique transcriptional profiles of immature neurons in aged human hippocampus across healthy, Alzheimer's disease, and resilient conditions, linking them to homeostasis and cognitive resilience.

This paper investigates sex-specific changes in ΔFOSB expression and co-activation networks in mice after long-term voluntary wheel running, revealing sex-dependent brain network reorganization.

This study shows that traumatic brain injury shifts adult hippocampal neural stem cell fate toward neurogenesis and away from astrogliogenesis, using single-cell RNA sequencing and spatial transcriptomics.

This study examines how early-life stress affects the synaptic proteome in Alzheimer's disease mouse models, revealing age- and pathology-dependent changes in mitochondrial and astrocytic proteins.

The paper identifies purinergic receptor expression patterns in specific brain regions associated with fatal suicidality in individuals with mood disorders.

This study investigates how chronic stress affects CRH signaling and neuronal activity in the BNST, linking these changes to anxiety-related behaviors in mice.