Laurent Givalois

This study examines how early-life handling and sex influence cognitive resilience and pathology in APP/PS1 mice over time, finding improved memory and reduced pathology in handled mice and better cognition in females despite greater pathology.

The paper shows that mGlu5 expression is asymmetrically distributed in the hippocampus of wild-type mice, and this asymmetry is lost in AD model mice, with left-specific inhibition of mGlu5 restoring memory and reversing pathology.

This paper develops a photoswitchable positive allosteric modulator of mGlu5 that activates the receptor in response to light, demonstrating reversible isomerization and light-dependent activity.