Requirement of FLCN tumor suppressor gene for mTORC1-mediated inhibition of TFE3 transcriptional activity
Hua Li, HyoungBin Oh, Benoit Viollet, Laura S. Schmidt, W. Marston Linehan, Vera P. Krymskaya, Seung-Beom Hong
This study shows that FLCN is required for mTORC1-mediated inhibition of TFE3 activity, which regulates lysosomal gene expression under metabolic stress.
bioRxiv · Jul 8, 2020 · PreprintCell Biology