Evolving copy number gains promote tumor expansion and bolster mutational diversification
Zicheng Wang, Yunong Xia, Lauren Mills, Αθανάσιος Ν. Νικολακόπουλος, Nicole Maeser, Scott M. Dehm, Jason M. Sheltzer, Ruping Sun
The paper estimates the arrival time of clonal copy number gains in tumors and shows they promote mutational diversification and malignant growth.
Nature Communications · Mar 6, 2024Peer-reviewedGenomics