Ruping Sun

LeafRank infers relative cell fitness from single-cell phylogenies in chromosomally unstable tumors, revealing fitness dynamics in ovarian cancer.

The paper estimates the arrival time of clonal copy number gains in tumors and shows they promote mutational diversification and malignant growth.

This paper uses computational modeling to show that metastatic-primary genomic divergence depends on tumor growth dynamics and variant detectability, revealing non-monotonic relationships in some scenarios.