Cholesterol metabolism is a potential therapeutic target in Duchenne Muscular Dystrophy
Fatima Amor, Ai Vu Hong, Guillaume Corre, Mathilde Sanson, Laurence Suel, S. Blaie, Laurent Servais, Thomas Voït, Isabelle Richard, David Israeli
This study identifies dysregulated miRNAs in DMD patients and mice, linking cholesterol metabolism and the mevalonate pathway to disease progression, with Simvastatin treatment showing therapeutic potential.
Journal of Cachexia Sarcopenia and Muscle · May 26, 2021Peer-reviewedGenetics