Hematopoietic differentiation is characterized by a transient peak of entropy at a single cell level.
Charles Dussiau, Agathe Boussaroque, Mathilde Gaillard, Clotilde Bravetti, Laila Zaroili, Camille A. Knosp, Chloé Friedrich, Philippe Asquier, Lise Willems, Laurent Quint, Didier Bouscary, Michaëla Fontenay, Thibault Espinasse, Adriana Pleșa, Pierre Sujobert, , Olivier Kosmider
The paper uses single-cell data to show that hematopoietic differentiation involves a transient peak of gene expression variability, suggesting a stochastic process with a stage of cellular indetermination.
BMC Biology · Mar 8, 2022Peer-reviewedSystems Biology