Chloé Friedrich

Pro-inflammatory role of granzyme K producing bystander CD8+ T cells in acute myeloid leukemia

This study identifies a pro-inflammatory role of Granzyme K-producing bystander CD8+ T cells in AML, which promote IL-8 secretion and may exacerbate disease progression.

Humanized in vivo bone marrow models orchestrate multi-lineage human hematopoietic cell development

This study characterizes a humanized in vivo bone marrow model, hOss, showing its impact on human hematopoietic development and clonal interactions.

Hematopoietic differentiation is characterized by a transient peak of entropy at a single cell level.

The paper uses single-cell data to show that hematopoietic differentiation involves a transient peak of gene expression variability, suggesting a stochastic process with a stage of cellular indetermination.