Michaëla Fontenay

This study integrates clinical and T-cell immune profiling to identify early biomarkers of response to CD3xBCMA bispecific antibody therapy in multiple myeloma.

This study identifies a pro-inflammatory role of Granzyme K-producing bystander CD8+ T cells in AML, which promote IL-8 secretion and may exacerbate disease progression.

The paper uses single-cell data to show that hematopoietic differentiation involves a transient peak of gene expression variability, suggesting a stochastic process with a stage of cellular indetermination.

ImmunoCluster provides an R package for analyzing high-dimensional cytometry data, enabling non-specialists to profile cellular heterogeneity through scalable analysis and visualization tools.

The paper examines TP53 allelic states in MDS patients, finding that bi-allelic targeting is linked to worse outcomes, while mono-allelic targeting does not differ from wild-type patients.