Refined cellular activity expression signatures provide a targeted framework to quantify phenotypic intra-tumor heterogeneity in single-cell data
Angèle Coutant, Lauriane Muller, Cyril Dégletagne, Frédérique Fauvet, Islam El Boudi, Christelle Chassot, Jenny Valladeau‐Guilemond, Nathalie Bendriss‐Vermare, Anne‐Pierre Morel, Maria Ouzounova, Pierre Saintigny, Alain Puisieux, Arnaud M. Vigneron, Pierre Martinez
The paper refines cellular activity expression signatures to better quantify phenotypic intra-tumor heterogeneity in single-cell data, showing high correlation with diversity indices and higher heterogeneity in patient tumors than cell lines.
bioRxiv · Dec 24, 2025 · PreprintCancer Biology