Cyril Dégletagne

The paper refines cellular activity expression signatures to better quantify phenotypic intra-tumor heterogeneity in single-cell data, showing high correlation with diversity indices and higher heterogeneity in patient tumors than cell lines.

This study identifies the netrin-1/UNC5B/TFF3 axis as a regulator of colorectal cancer stem cell self-renewal and shows that targeting it with NP137 enhances chemotherapy efficacy in preclinical models.

The paper identifies Perlecan as a factor that influences muscle stem cell re-quiescence, showing its age-related changes and therapeutic potential.

This study introduces a method to generate high-quality single-nucleus transcriptomic data from FFPE samples using recent single-cell genomic technology.

The paper maps CB2 expression in mouse brain and shows its regulation in microglia under different inflammatory conditions.