Jenny Valladeau‐Guilemond

The paper examines the spatial organization of dendritic cell subsets in NSCLC patients treated with anti-PD1 and finds that cDC1-driven patterns correlate with prolonged ICB response.

The paper refines cellular activity expression signatures to better quantify phenotypic intra-tumor heterogeneity in single-cell data, showing high correlation with diversity indices and higher heterogeneity in patient tumors than cell lines.

IntegrAlign integrates multiimmunofluorescence panels through image alignment, achieving sub-cellular precision and improving spatial analysis of tumor microenvironments.

This study identifies HERV-derived epitopes as potential targets for T-cell immunotherapies in ovarian cancer, showing their expression in tumors and immunogenicity in patients.

This study maps spatial tumour-immune interactions in melanoma and identifies how their organization affects anti-PD1 therapy efficacy.

This study examines the spatial organization of dendritic cell (DC) subsets and their interactions with CD8+ T cells in melanoma patients, finding that proximity between cDC1 and CD8+ T cells correlates with response to immune checkpoint inhibitors.

The paper identifies a shared neoepitope from non-canonical c-MYC translation in cancer cells that activates T cells to kill tumors without harming normal cells.