Phage-encoded sRNA counteracts xenogenic silencing in pathogenic E. coli
Pranita Poudyal, Brandon M. Sy, Daniel G. Mediati, Michael Payne, Vibhuti Nandel, Dougall M. Norris, Sean P. McAteer, Asim Ullah, Serena Li, Lawrence Menz, Shafagh A. Waters, Timothy J. Dallman, Matthew A. B. Baker, Ruiting Lan, David L. Gally, Jai Justin Tree
The paper identifies a prophage-encoded sRNA, HnrS, that counteracts xenogenic silencing by repressing Hha, enabling virulence gene expression in E. coli.
bioRxiv · Nov 27, 2025 · PreprintMicrobiology