Single cell transcriptomics identifies master regulators of dysfunctional pathways in SOD1 ALS motor neurons
Seema Chandramohan Namboori, Patricia Thomas, Ryan M. Ames, Sophie Hawkins, Lawrence O. Garrett, Craig R. G. Willis, Alessandro Rosa, Lawrence Walter Stanton, Akshay Bhinge
The paper uses single cell transcriptomics to identify master regulators of dysfunctional pathways in SOD1 ALS motor neurons, finding SMAD2 activation as a key driver of neurodegeneration.
bioRxiv · Mar 9, 2021 · PreprintGenomics