Hierarchical decoding of targeting tripeptide motif by the cytosolic iron-sulfur cluster assembly targeting complex
Anastasiya Buzuk, Omeir Khan, Soyoon Kang, Leah Yim, Sándor Vajda, Deborah L. Perlstein
This paper defines the molecular basis for TCR peptide recognition by the CIA targeting complex using binding measurements, bioinformatics, and structural modeling, revealing a hierarchy of physicochemical determinants.
bioRxiv · Apr 8, 2026 · PreprintBiochemistry