Deborah L. Perlstein

Promiscuous Metal Site in Hepatitis B Virus X Protein Binds anFe-S Cluster

This study identifies Fe-S cluster ligands in HBx, showing it binds both Fe-S and Zn, with implications for HBV replication and drug targeting.

Discovery of a cluster in the PRRSV Nsp1α leader protease reveals host-virus interplay in its downstream functions

The paper identifies a [4Fe-4S] cluster in PRRSV Nsp1α leader protease, showing its role in modulating protease activity and host-virus interactions.

Hierarchical decoding of targeting tripeptide motif by the cytosolic iron-sulfur cluster assembly targeting complex

This paper defines the molecular basis for TCR peptide recognition by the CIA targeting complex using binding measurements, bioinformatics, and structural modeling, revealing a hierarchy of physicochemical determinants.

Nar1 binds the cytosolic iron sulfur cluster assembly targeting complex via a bipartite interaction interface

This study identifies the molecular mechanism by which Nar1 binds the CTC through two distinct interfaces, facilitating Fe-S cluster transfer during protein maturation.

Getting Started with Machine Learning for Experimental Biochemists and Other Molecular Scientists

This paper provides step-by-step tutorials on four machine learning methods for experimental molecular scientists without prior ML or coding experience.

The Cia1 and Cia2 subunits of the CTC mediate recognition of apo-FeS proteins with a C-terminal targeting complex recognition motif

This study identifies the Cia1-Cia2 interface as critical for recognizing TCR motifs on client proteins, revealing a broader role for CIAO2A in iron-sulfur protein maturation.