Cancer BiologybioRxivPreprint
Miniaturized Traceless Staudinger Ligation Enables Direct-to-Biology Screening of Potent BRD4 PROTACs
Marko Mitrović, Leann Schüffner, Saran Aswathaman Sivashanmugam…·Kerstin Hiesinger
This paper develops a miniaturized traceless Staudinger ligation method to rapidly discover potent BRD4-targeting PROTACs by screening crude reaction mixtures directly in biological assays.
DOI 10.64898/2026.11.07.765033