Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity
Capria Rinaldi, Christopher S Waters, Zizheng Li, Karl Kumbier, Lee Rao, R. Jeremy Nichols, Matthew P. Jacobson, Lani F. Wu, Steven J. Altschuler
The paper investigates how GTPase and kinase domain mutations in LRRK2 affect endosomal localization and Rab phosphorylation, finding that GTPase-inactivating mutants lead to more LRRK2+ endosomes and higher Rab phosphorylation.
Cell Reports · May 1, 2023Peer-reviewedSystems Biology