Whole-Colony Modeling of Escherichia coli
Christopher John Skalnik, Eran Agmon, Ryan K. Spangler, Lee Talman, Jerry H. Morrison, Shayn M. Peirce, Markus W. Covert
The paper develops a whole-colony model of E. coli integrating single-cell mechanisms with population-level interactions, showing that AmpC expression, not AcrAB-TolC, drives antibiotic survival.
bioRxiv · Apr 27, 2021 · PreprintSystems Biology