Markus W. Covert

This study shows CD16a mediates NK cell activation by transducing piconewton forces, integrating biochemical and biophysical signals to enhance ADCC.

The paper integrates multiplexed imaging and multiscale modeling to show that T cell phenotype influences tumor phenotype conversion, critical for therapeutic efficacy.

The paper identifies a dynamic HIF1alpha-PPARgamma circuit that both promotes and represses lipid accumulation during adipogenesis, revealing a mechanism for adipocyte dysfunction in obesity.

This paper introduces Vivarium, a software tool for building integrative multiscale models in computational biology, demonstrating its utility by combining multiple modeling frameworks.

The paper develops a whole-colony model of E. coli integrating single-cell mechanisms with population-level interactions, showing that AmpC expression, not AcrAB-TolC, drives antibiotic survival.