Author

Lehan Zhang

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Mingyue ZhengiD· 2 shared Kun WangiD· 1 shared Ning Qu· 1 shared Shengkun Ni· 1 shared Sulin ZhangiD· 1 shared Xiangtai KongiD· 1 shared Xiaochu Tong· 1 shared Xiaolong WuiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioinformatics

Mingyue ZhengORCID

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2 papers

Recent·Most cited

GDOP: A graph convolutional network-based drug "on-target" pathway prediction algorithm

Xiaolong Wu, Lehan Zhang, Mingyue Zheng

GDOP predicts drug 'on-target' pathways using graph convolutional networks, achieving high AUC-ROC and Top10 accuracy on LINCS data.

bioRxiv · Mar 3, 2024 · PreprintBioinformatics

TranSiGen: Deep representation learning of chemical-induced transcriptional profile

Xiaochu Tong, Ning Qu, Xiangtai Kong, Shengkun Ni, Kun Wang, Lehan Zhang, Yiming Wen, Sulin Zhang, Xutong Li, Mingyue Zheng

TranSiGen denoises and reconstructs chemical-induced transcriptional profiles using deep generative modeling, effectively predicting differential expression genes and serving as alternative phenotype information for drug discovery.

bioRxiv · Nov 12, 2023 · PreprintBioinformatics