Towards One-Step and Universal Synthesis of Hypermodified Uracil Nucleosides: acp3U and cmnm5U
Ewa Mejdr, Lena Heinickel, Thomas Carell, Ivana Mejdrová
The paper develops a single-step synthesis method for acp3U and cmnm5U phosphoramidites, enabling the creation of oligonucleotides with hypermodified nucleobases.
bioRxiv · Sep 26, 2025 · PreprintMolecular Biology