Thomas Carell

This study identifies YhcC as an anaerobic alternative to MnmC for demodifying cmnm5s2U to nm5s2U in E. coli tRNA.

This study shows that the carbocyclic antimetabolite cAzadC increases TET2 expression and 5hmdC levels, leading to reactivation of anti-tumor responses in AML models.

This study assesses ALKBH1 activity in vitro and in human cell lines using mass spectrometry, finding no significant impact on tRNA modifications under optimal conditions.

This paper develops a method to generate pure 5hmdC-DNA using a Tet3 double-mutant and reduction steps, enabling applications in epigenetic research and diagnostics.

The paper shows TET3 and MECP2 interact to regulate neuronal maturation, with TET3 critical for functional development and MECP2 inhibiting TET3 activity.

The paper develops a single-step synthesis method for acp3U and cmnm5U phosphoramidites, enabling the creation of oligonucleotides with hypermodified nucleobases.

This study shows that reducing m6A RNA levels in E. coli decreases T5 phage infection efficiency but not other phages.

The paper demonstrates that geranylated non-canonical nucleotides enable RNA to anchor to lipid membranes, facilitating a primitive peptide synthesis system in a protocellular environment.

This paper introduces a method to generate densely labeled oligonucleotides for detecting small genomic elements using FISH in single cells.

The paper identifies and validates small-molecule inhibitors of TRMT2A that reduce polyQ aggregation and cell death in human cells.

This study identifies TENT4A as a regulator of DNA-damage tolerance through multiple pathways, with mutations in these pathways linked to endometrial cancer.

The paper identifies DPPA3 as a driver of genome-wide passive DNA demethylation in mammals, showing it can bypass TET protein requirements and function across species.