Peripheral T Helper Cells Dominate the Synovial CD4⁺ T Cell Compartment in Systemic Juvenile Idiopathic Arthritis and Are Shaped by IL-1β and IL-18
Johannes Dirks, Jonas Fischer, Leon Harrer, Claudia Bracaglia, Giusi Prencipe, Manuela Pardeo, Silvia Magni‐Manzoni, Ivan Caiello, Annette Holl‐Wieden, Hermann Joseph Girschick, Christoph Kessel, Henner Morbach
This study identifies peripheral T helper (Tph) cells as dominant in sJIA synovial CD4+ T cells, driven by IL-1β and IL-18, linking them to chronic arthritis.
bioRxiv · Jul 3, 2025 · PreprintImmunology