Author

Christoph Kessel

University Hospital MünsterORCID 0000-0002-0638-2949Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Claudia BracagliaiD· 2 shared Giusi PrencipeiD· 2 shared Henner MorbachiD· 2 shared Ivan CaielloiD· 2 shared Johannes DirksiD· 2 shared Manuela PardeoiD· 2 shared Aljoscha Swoboda· 1 shared Annette Holl‐Wieden· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersImmunology

Claudia BracagliaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Peripheral T Helper Cells Dominate the Synovial CD4⁺ T Cell Compartment in Systemic Juvenile Idiopathic Arthritis and Are Shaped by IL-1β and IL-18

Johannes Dirks, Jonas Fischer, Leon Harrer, Claudia Bracaglia, Giusi Prencipe, Manuela Pardeo, Silvia Magni‐Manzoni, Ivan Caiello, Annette Holl‐Wieden, Hermann Joseph Girschick, Christoph Kessel, Henner Morbach

This study identifies peripheral T helper (Tph) cells as dominant in sJIA synovial CD4+ T cells, driven by IL-1β and IL-18, linking them to chronic arthritis.

bioRxiv · Jul 3, 2025 · PreprintImmunology

The systemic JIA synovial fluid environment supports development and prevalence of specific inflammatory T helper cell phenotypes

Susanne Schleifenbaum, Aljoscha Swoboda, Johannes Dirks, Claudia Bracaglia, Ivan Caiello, Tanja Hinze, Sven Hardt, Giusi Prencipe, Giusyda Tarantino, Manuela Pardeo, Sabrina Fuehner, Carolin Park, Claas H. Hinze, Helmut Wittkowski, Daniel Windschall, , Christoph Kessel

This study compares how synovial fluid from systemic juvenile idiopathic arthritis (sJIA) and JIA patients influences T helper cell polarization, showing sJIA SF promotes a specific Tph phenotype linked to IL-1β, IL-18, and GM-CSF.

bioRxiv · Jul 1, 2025 · PreprintImmunology