Author

Johannes Dirks

Universitätsklinikum WürzburgORCID 0000-0002-1244-6670Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Christoph KesseliD· 2 shared Claudia BracagliaiD· 2 shared Giusi PrencipeiD· 2 shared Henner MorbachiD· 2 shared Ivan CaielloiD· 2 shared Manuela PardeoiD· 2 shared Aljoscha Swoboda· 1 shared Annette Holl‐Wieden· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersImmunology

Christoph KesselORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJul 3, 2025

Peripheral T Helper Cells Dominate the Synovial CD4⁺ T Cell Compartment in Systemic Juvenile Idiopathic Arthritis and Are Shaped by IL-1β and IL-18

Johannes Dirks, Jonas Fischer, Leon Harrer…·Henner Morbach

This study identifies peripheral T helper (Tph) cells as dominant in sJIA synovial CD4+ T cells, driven by IL-1β and IL-18, linking them to chronic arthritis.

1 citation

humanscRNA-seq

ImmunologybioRxivPreprintJul 1, 2025

The systemic JIA synovial fluid environment supports development and prevalence of specific inflammatory T helper cell phenotypes

Susanne Schleifenbaum, Aljoscha Swoboda, Johannes Dirks…·Christoph Kessel

This study compares how synovial fluid from systemic juvenile idiopathic arthritis (sJIA) and JIA patients influences T helper cell polarization, showing sJIA SF promotes a specific Tph phenotype linked to IL-1β, IL-18, and GM-CSF.

DOI 10.1101/2025.07.01.661738

humanproteomics