Leslie Bridges

Cryo-EM evidence for a common factor in Alzheimer's and other neurodegenerations

The paper uses cryo-EM maps to identify a common molecular factor in neurodegenerative diseases, suggesting RNA as a potential candidate.

Replicating RNA as a component of scrapie fibrils

The paper identifies RNA as a potential genetic component in scrapie fibrils using in silico analysis of cryo-EM maps, challenging the protein-only prion hypothesis.

RNA as a component of fibrils from Alzheimer's disease and other neurodegenerations

The paper identifies RNA as a component of fibrils in neurodegenerative diseases and proposes a new hypothesis involving RNA-protein complexes.