Contact dependent suppression of Clostridioides difficile sporulation by enterococci requires the endocarditis and biofilm pilus
Alicia K. Wood, Caspar S. Carson, Holly R Neubauer, Lesly-Hannah Gutierrez, Mofiyinfoluwa Adeoye, Angus Johnson, Ana Beatriz Garcez Buiatte, Bryce Chong, Laura C. Cook, Adam M. Session, Cheryl P. Andam, Peter T. McKenney
This study shows that enterococci reduce C. difficile sporulation through contact-dependent mechanisms involving surface pili, suggesting a role for gut microbiota in controlling spore formation.
bioRxiv · Apr 23, 2026 · PreprintMicrobiology