De Novo Design of a Protein Binder to Probe Gas Channel and Enhance the Oxygen Tolerance of Hydrogenase
Xuan Sun, Qi xiao, Nan Zhang, Wenjin Li, Hang Luo, Yanxin Gao, Leyan Zhang, Yilin Fan, Peiyu Jiang, Yucen Huang, Wencheng Fu, Liyun Zhang
This study designs AI-guided protein binders to map O2 diffusion pathways in hydrogenase, enhancing oxygen tolerance by blocking primary channels.
Angewandte Chemie · Aug 26, 2026Peer-reviewedBiochemistry