Author

Xuan Sun

Shanghai Jiao Tong UniversityORCID 0000-0003-2648-2637Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Geng WuiD· 1 shared Hang LuoiD· 1 shared Leyan Zhang· 1 shared Liyun ZhangiD· 1 shared Nan ZhangiD· 1 shared Peiyu JiangiD· 1 shared Qi xiaoiD· 1 shared Wen WangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Geng WuORCID

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2 papers

Recent·Most cited

BiochemistryAngewandte ChemiePeer-reviewedAug 26, 2026

De Novo Design of a Protein Binder to Probe Gas Channel and Enhance the Oxygen Tolerance of Hydrogenase

Xuan Sun, Qi xiao, Nan Zhang…·Liyun Zhang

This study designs AI-guided protein binders to map O2 diffusion pathways in hydrogenase, enhancing oxygen tolerance by blocking primary channels.

DOI 10.1002/ange.6395554

E. coliprotein structure

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Cancer BiologyInternational Journal of Molecular SciencesPeer-reviewedOct 10, 2025

Targeted inhibition of colorectal carcinoma using a designed CEA-binding protein to deliver TCF/LEF transcription factor decoy DNA and p53 protein

Wen Wang, Xuan Sun, Geng Wu

This paper develops a targeted therapy for colorectal carcinoma using a CEA-binding protein to deliver transcription factor decoy DNA and p53 protein, showing suppression of tumor growth.

2 citations

humanproteomics

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