Author

Yucen Huang

Nankai University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Annelies StevaertiD· 1 shared Barbara SeliskoiD· 1 shared Benjamin Van LoyiD· 1 shared Bert VanmecheleniD· 1 shared Bruno CanardiD· 1 shared Bruno Ribeiro de Castro Ramos· 1 shared Dong LiuiD· 1 shared Elisabetta GroaziD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperMicrobiology

Annelies StevaertORCID

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2 papers

Recent·Most cited

Mechanistic insights into coronavirus inhibition by a distinct base-modified adenosine analog targeting the viral polymerase

Nikolai Bakirtzoglou, Barbara Selisko, Yucen Huang, Peng Nie, Bruno Ribeiro de Castro Ramos, Ria Van Berwaer, Lieselotte Schurmans, Véronique Fattorini, Yu Zhou, Yufan Pan, Xiaoxia An, Julie Vandeput, Benjamin Van Loy, Bert Vanmechelen, Piet Maes, , Annelies Stevaert

This paper investigates the mechanism of 6-ethyl-modified 7-deazaadenosine (EDA) as a coronavirus inhibitor, showing it stalls viral polymerase without causing mutagenesis.

bioRxiv · Oct 29, 2026 · PreprintMicrobiology

De Novo Design of a Protein Binder to Probe Gas Channel and Enhance the Oxygen Tolerance of Hydrogenase

Xuan Sun, Qi xiao, Nan Zhang, Wenjin Li, Hang Luo, Yanxin Gao, Leyan Zhang, Yilin Fan, Peiyu Jiang, Yucen Huang, Wencheng Fu, Liyun Zhang

This study designs AI-guided protein binders to map O2 diffusion pathways in hydrogenase, enhancing oxygen tolerance by blocking primary channels.

Angewandte Chemie · Aug 26, 2026Peer-reviewedBiochemistry