An Atlas of Extrachromosomal DNA Structures Illuminates Its Evolution and Biogenesis in Cancer
Chee‐Hong Wong, Kuo‐Chen Wei, Kuan-Yu Kung, Li-Hao Yang, Yin-Cheng Huang, C. Shing Huang, I-Jiuan Chung, Huang Meng-fan, Pei‐Hua Peng, Meihong Li, Chew Yee Ngan, Kou-Juey Wu, Chia‐Lin Wei
The paper maps ecDNA structures in glioblastoma using long-read sequencing and ecLego3, revealing structural variation, evolutionary dynamics, and transcriptional links to tumor adaptation.
bioRxiv · Dec 25, 2025 · PreprintCancer Biology