Chee‐Hong Wong

MitoScope is a long-read sequencing workflow for mitochondrial genome analysis that improves sensitivity and precision in variant detection and NUMT profiling.

The paper maps ecDNA structures in glioblastoma using long-read sequencing and ecLego3, revealing structural variation, evolutionary dynamics, and transcriptional links to tumor adaptation.

This study shows ecDNA forms nuclear condensates and reorganizes chromatin to enhance oncogenic transcription across cancer types.

This study uses nanopore sequencing to identify structural variants in breast cancer with high specificity and sensitivity, revealing repetitive DNA as a major source of variation.

This paper introduces a method to analyze multiplex chromatin interactions with single-molecule precision and shows they contribute to topologically associated domains and gene regulation.