Simple sequence repeats power Staphylococcus aureus adaptation
Romain Guérillot, Ashleigh S. Hayes, Abderrahman Hachani, Stefano G. Giulieri, Liam Donovan, Louise M. Judd, Liam K. R. Sharkey, Anders Gonçalves da Silva, Torsten Seemann, Timothy Paul Stinear, Benjamin P. Howden
This study identifies simple sequence repeats (SSRs) as key drivers of genetic heterogeneity and rapid adaptation in Staphylococcus aureus through loss-of-function mutations and phase-variable evolution.
bioRxiv · Jul 8, 2025 · PreprintMicrobiology