Abderrahman Hachani

Characterisation of novel Campylobacter jejuni Type VI secretion system (T6SS) effectors and exploration of the roles of the C. jejuni T6SS in bacterial antagonism and human host cell interaction

This study identifies two novel T6SS effectors in C. jejuni and shows their role in bacterial antagonism and host cell interaction.

Integrated multi-omics reveals coordinated Staphylococcus aureus metabolic, iron transport and stress responses to human serum

This study integrates multi-omic data from Staphylococcus aureus exposed to human serum to identify genetic factors critical for survival, revealing interconnected metabolic, iron transport, and stress response mechanisms.

A Practical Resource for Multi-Omics Data Integration in Microbial Systems

This paper introduces an R-based workflow for integrating microbial multi-omics data, enabling analysis of transcriptomic, proteomic, and metabolomic datasets and generating pathway-level insights.

Regulation of airway fumarate by host and pathogen promotes S. aureus pneumonia

This study shows that fumarate, regulated by host and pathogen, limits S. aureus growth by blocking metabolic pathways, while FumC enables adaptation through fumarate degradation and utilization.

Simple sequence repeats power Staphylococcus aureus adaptation

This study identifies simple sequence repeats (SSRs) as key drivers of genetic heterogeneity and rapid adaptation in Staphylococcus aureus through loss-of-function mutations and phase-variable evolution.

PI3Kδ Bridges Microbial Surveillance with Antigen Presentation to Reinforce Intestinal Immunity

This study shows PI3Kδ is critical for dendritic cell function in intestinal immunity by linking microbial sensing to antigen presentation and T-cell activation.

Quorum sensing and DNA methylation play active roles in clinical Burkholderia phase variation

This study identifies quorum sensing and adenosine DNA methylation as two antagonistic systems controlling phase variation in Burkholderia ambifaria clinical isolates.

Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections

This study identifies genome degradation and convergent mutations in Staphylococcus aureus during severe infections, linking them to adaptation and clinical outcomes.